The Relationship of Polymorphism of RFC-I Gene on Methotrexate Serum Level and Related Toxicity in Pediatric Acute Lymphoblastic Leukemia

Zaker F^1,2*, Ansari S³, Toosi B², Sayadi M⁴ and Sharafi H²

¹Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran

²Departement of Hematology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran

³Departement of Pediatric Hematology and Oncology, Aliasghar Hospital, Iran University of Medical Sciences, Tehran, Iran

⁴Departement of Hematology, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran

^*Corresponding Author: Zaker F, School of Allied Medical Sciences and Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran, Tel: +982186701021 Email: