Synthesis, Biological Evaluation and Modeling Studies of New Pyrido[3,4-b] indole Derivatives as Broad-Spectrum Potent Anticancer Agents

Shivaputra A Patil^1,6, James K Addo¹, Hemantkumar Deokar^1,2, Shan Sun¹, Jin Wang¹, Wei Li¹, D Parker Suttle³, Wei Wang^4,5, Ruiwen Zhang^4,5* and John K Buolamwini^1,2*

¹Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 847 Monroe Avenue, Suite 327, Memphis, TN 38163, USA, E-mail: john.buolamwini@rosalindfranklin.edu

²Department of Pharmaceutical Sciences, College of Pharmacy, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, 60064, USA, E-mail: john.buolamwini@rosalindfranklin.edu

³Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, 38163, USA, E-mail: john.buolamwini@rosalindfranklin.edu

⁴Department of Biomedical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA, E-mail: john.buolamwini@rosalindfranklin.edu

⁵Cancer Biology Center, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA, E-mail: john.buolamwini@rosalindfranklin.edu

⁶Present address: Department of Pharmaceutical Sciences, College of Pharmacy, Rosalind Franklin University of Medicine and Science, Room HSB 2.627, 3333 Green Bay Road, North Chicago, Illinois, 60064, USA, E-mail: john.buolamwini@rosalindfranklin.edu

^*Corresponding Author(s): Ruiwen Zhang, Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, 1300 S. Coulter St., Amarillo, TX 79106, USA, Tel: 806-414-9248, Fax: 806-356-4034 Email: John K Buolamwini, Department of Pharmaceutical Sciences, College of Pharmacy, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, United States, Tel: 847-578-8341 Email: