Quantitative Proteomics Analysis of Differentially Expressed Proteins Involved in Renal Clear Cell Carcinoma by Shotgun Approach Coupled with Stable Isotope Dimethyl Labeling

Shih-Shin Liang^1,2#, Chao-Jen Kuo^3#, Shu-Wen Chi³, Wen-Jeng Wu⁴, Shui-Tein Chen^5,6 and Shyh-Horng Chiou^3,5*

¹Department of Biotechnology, College of Life Science, Kaohsiung Medical University, Taiwan

²Center for Research Resources and Development, Kaohsiung Medical University, Taiwan

³Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan

⁴Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Taiwan

⁵Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

⁶Institute of Biochemical Sciences, College of Life Science, National Taiwan University, Taipei, Taiwan

^#Contributed equally to this work

^*Corresponding Author: Shyh-Horng Chiou, Quantitative Proteomics Center and Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan, Tel: +886-7-3220377, Fax: +886-7-3133434