QSAR Model Generation of Phthalazinones as Poly (ADP-Ribose) Polymerase Inhibitors by the Genetic Algorithm and Multiple Linear Regression (GA-MLR) Method: A Ligand-Based Approach for Cancer Drug Design

George Oche Ambrose^1*, Olanrewaju John Afees^2,3, Uchechukwu Joseph Kalu⁴, Abiodun Wisdom Oshireku⁵, Afolayan Daniel Todimu¹, Olayinka Emmanuel Oluwasegun⁶, Toba Olatoye¹, Fagbemi Ranti-Ade Rebecca¹ and Adekunle Precious¹

¹Department of Biochemistry, University of Ilorin, Ilorin, Nigeria

²Department of Anatomy, University of Ilorin, Ilorin, Nigeria

³Ben Carson School of Medicine, Ileshan-Remo, Nigeria

⁴University of Calabar, Calabar, Nigeria

⁵University of Ibadan, Ibadan, Nigeria

⁶Olabisi Onabanjo University, Ogun State, Nigeria

^*Corresponding Author: George Oche Ambrose, Department of Biochemistry, University of Ilorin, Ilorin, Nigeria, Tel: +031-821304, Fax: + 031-221937

Keywords: Parp-1; GA-MLR; Phthalazinones; Y-randomization

Introduction