Nucleotide-free Crystal Structure of Nucleotide-binding Domain 1 from Human ABCC1 Supports a ‘General-Base Catalysis’ Mechanism for ATP Hydrolysis

Vincent Chaptal^1*, Sandrine Magnard¹, Virginie Gueguen-Chaignon², Pierre Falson¹, Attilio Di Pietro¹ and Hélène Baubichon-Cortay¹

¹Mechanisms and Modulation of Drug Resistance Team, Equipe Labellisée Ligue 2014, BMSSI UMR5086, CNRS-University Lyon-1, IBCP, 7 Passage du Vercors, 69367 Lyon, France

²Protein Science Facility, Institute of Biology and Chemistry of Proteins, SFR Biosciences/FR3302, 7 Passage du Vercors, 69367 Lyon, France

^*Corresponding Author: Vincent Chaptal, Mechanisms and Modulation of Drug Resistance Team, Institute of Biology and Chemistry of Proteins, BMSSI UMR 5086 CNRS/University Of Lyon 1, 7 Passage Du Vercors, 69367 Lyon, France Email: