Mutual Exclusivity of MED12/MED12L, MED13/13L, and CDK8/19 Paralogs Revealed within the CDK-Mediator Kinase Module

Danette L. Daniels^1*, Michael Ford^2*, Marie K. Schwinn¹, Hélène Benink¹, Matthew D.Galbraith^3,4, Ravi Amunugama², Richard Jones², DavidAllen², NorikoOkazaki⁵, Hisashi Yamakawa⁵, Futaba Miki⁵, Takahiro Nagase⁵, Joaquín M.Espinosa^3,4 and Marjeta Urh¹

¹Promega Corporation, 2800 Woods Hollow Road, Madison, WI 53711, USA

²MSBioworks LLC, 3950 Varsity Drive, Ann Arbor, MI 48108, USA

³Howard Hughes Medical Institute, USA

⁴Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado, 80309, USA

⁵Kazusa DNA Research Institute, Kisarazu 292-0818, Japan

^*Corresponding Author(s): Danette L. Daniels, Promega Corporation, 2800 Woods Hollow Road, Madison, WI 53711, USA, Tel: (608) 274-4330, Fax: (608) 277-2601 Michael Ford, MS Bioworks LLC, 3950 Varsity Drive, Ann Arbor, MI 48108, USA, Tel: (734) 929-5083, Fax: (734) 929-4637