Journal of Clinical Toxicology

Journal of Clinical Toxicology
Open Access

ISSN: 2161-0495

Research Article - (2011) Volume 1, Issue 2

Monocarboxylate Transporter Inhibition with Osmotic Diuresis Increases γ-Hydroxybutyrate Renal Elimination in Humans: A Proof-of-Concept Study

Marilyn E. Morris1*, Bridget L. Morse1, Gloria J. Baciewicz2, Matthew M. Tessena2, Nicole M. Acquisto3, David J. Hutchinson4 and Robert DiCenzo5
1Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY (Morris and Morse), USA
2Department of Psychiatry, University of Rochester, University of Rochester Medical Center, Rochester, NY (Baciewicz and Tessena), USA
3Departments of Pharmacy and Emergency Medicine, University of Rochester, University of Rochester Medical Center, Rochester, NY (Acquisto), USA
4Department of Pharmacy Practice, School of Pharmacy, St. John Fisher College, Rochester, NY (Hutchinson), USA
5Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, NY (DiCenzo), USA
*Corresponding Author: Marilyn E. Morris, University at Buffalo, 527 Hochstetter Hall Buffalo, NY 14260, USA, Tel: (716) 645-4839, Fax: (716) 645-3693 Email:

Abstract