Monocarboxylate Transporter Inhibition with Osmotic Diuresis Increases γ-Hydroxybutyrate Renal Elimination in Humans: A Proof-of-Concept Study

Marilyn E. Morris^1*, Bridget L. Morse¹, Gloria J. Baciewicz², Matthew M. Tessena², Nicole M. Acquisto³, David J. Hutchinson⁴ and Robert DiCenzo⁵

¹Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY (Morris and Morse), USA

²Department of Psychiatry, University of Rochester, University of Rochester Medical Center, Rochester, NY (Baciewicz and Tessena), USA

³Departments of Pharmacy and Emergency Medicine, University of Rochester, University of Rochester Medical Center, Rochester, NY (Acquisto), USA

⁴Department of Pharmacy Practice, School of Pharmacy, St. John Fisher College, Rochester, NY (Hutchinson), USA

⁵Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, NY (DiCenzo), USA

^*Corresponding Author: Marilyn E. Morris, University at Buffalo, 527 Hochstetter Hall Buffalo, NY 14260, USA, Tel: (716) 645-4839, Fax: (716) 645-3693 Email: