Matrix Metalloproteinase-9 Triggers the Gap Junction Impairment and Somatosensory Neuronal Dysfunction in Septic Encephalopathy

Huan Wang^1#, Yukio Imamura^2,3*#, Naoya Matsumoto², Nao Yoshikawa⁴, Junichiro Nakagawa², Kazuma Yamakawa², Tomoki Yamada², Yuki Murakami³, Satoko Mitani³, Takashi Jin⁵, Hiroshi Ogura², Takeshi Shimazu² and Akitoshi Seiyama⁴

¹Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, Zhejiang University, Hangzhou, China

²Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Japan

³Unit for Liveable Cities, Kyoto University of Graduate School of Engineering and Medicine, Kyoto, Japan

⁴Human Health Science, Kyoto University Graduate School of Medicine, Kyoto, Japan

⁵Laboratory for Nano-bio Probes, Quantitative Biology Center, Japan

^#Contributed equally to this work

^*Corresponding Author: Yukio Imamura, Unit for liveable cities, Kyoto University Graduate School Of Engineering And Medicine, Japan, Tel: +81-75-751-3970, Fax: 81-75-751-3970 Email: