Intoxication with Calcium Channel Blockers and Other Highly Protein-Bound Drugs: Why Use MARS? Two Clinical Case Reports

Juan José García Martínez Martínez^1,2*, Frédéric Mollard¹, Frédéric J. Baud^3,4,5 and Karim Bendjelid^1,2,6

¹Intensive Care Unit, Geneva University Hospitals, 4 Rue Gabrielle-Perret-Gentil, 1205 Geneva, Switzerland

²Faculty of Medicine, University of Geneva, Geneva, Switzerland

³Adult Intensive Care Unit, Department of anesthesiology and intensive care and SAMU 75, CHU Necker-Enfants Malades; Assistance Publique - Hôpitaux de Paris, Paris, France

⁴EA 7323, Pharmacologie pédiatrique, 75015 Paris, France

⁵University Paris Sorbonne Cité, Paris Diderot, Paris, France

⁶Geneva Hemodynamic Research Group, Geneva, Switzerland

^*Corresponding Author: Juan José García Martínez Martínez, Hôpitaux Universitaires de Genève, Service Des Soins Intensifs, 4 Rue Gabrielle-Perret-Gentil, 1205 Genève, Switzerland, Tel: 0041767356684, Fax: 41223729105 Email:

Keywords: MARS; Albumin dialysis; Highly protein-bound drugs; Intoxication; Overdose

Introduction