Induction of Hypoxia Inducible Factor Rather than Modulation of Collagen Metabolism Improves Cardiac Function and Reduces Left Ventricular Hypertrophy after Aortocaval Shunt in Rats

Sebastian Philipp^1,2*, Jens Fielitz^2,3, Wanja M. Bernhardt^4,6, Jan Steffen Jürgensen⁴, Evelyn Schuch³, Kai-Uwe Eckardt³, Vera Regitz-Zagrosek³ and Roland Willenbrock^1,6

¹Department of Cardiology, Elbeklinikum Stade, Stade, Germany

²Department of Cardiology, CVK, Charité Universitätsmedizin Berlin, Germany

³Center for Gender in Medicine (GiM) and Cardiovascular Research Center (CCR), Charité Universitätsmedizin Berlin, Germany

⁴Department of Internal Medicine, Charité, Campus Virchow Clinic, Berlin, Germany

⁵Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen Nuernberg, Erlangen, Germany

⁶St. Elisabeth Hospitals, Halle, Germany

^*Corresponding Author: Sebastian Philipp, Department of Cardiology, Elbeklinikum Stade Bremervörder Str. 111, 21682 Stade, Germany, Tel: +49-4141-971450 Email: