In silico Analysis of 2, 4-Substituted Heterocycles and Glutamic Acid Containing Antifolates as Inhibitors of Malarial (Plasmodium falciparum) Protein, Dihydrofolate Reductase-Thymidylate Synthase

Jawaria Munir¹, Zeeshan Iqbal¹, Daniel C Hoesli^1,2, Abdul Rauf Shakoori^3* and Nasir Uddin^1*

¹Institute of Molecular Sciences & Bioinformatics, Lahore, Pakistan

²Panjwani Institute of Molecular Medicine and Drug Research, University of Karachi, Karachi, Pakistan

³School of Biological Sciences, University of Punjab, Quaid-i-Azam Campus, Lahore, Pakistan

^*Corresponding Author(s): Dr. Abdul Rauf Shakoori, Distinguished National Professor and Director, School of Biological Sciences, University of the Punjab, Quaid-i-Azam Campus, Lahore, Pakistan, Tel: 92-42-99230133, Fax: 92-42- 99230980 Prof. Nasir Uddin, Institute of Molecular Sciences and Bioinformatics, 28-Nisbet Road, Opp. Dayal Singh Library, Lahore, Pakistan