Identification of Fat Storage-Inducing Transmembrane Proteins 1 and 2 as Putative Therapeutic Targets for Heart Failure by Integrated Analysis of Proteome and Transcriptome

Natsumi Nishihama^1*, Yuki Abe², Kazuishi Kubota³, Takahiro Nagayama⁴, Takehiro Hirai⁵, Kenjiro Ueda⁶, Kenji Nakamaru⁷, Tsuyoshi Hirata³, Keiichi Fukuda⁸, Ryuta Koishi¹ and Shinji Makino⁸

¹Venture Science Laboratories, R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan

²Biologics & Immuno-Oncology Laboratories, Oncology Function, R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan

³Research Management Department, Daiichi Sankyo RD Novare Co., Ltd., 1-16-13, Kitakasai, Edogawa-ku, Tokyo 134-8630, Japan

⁴Rare Disease Laboratories, R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan

⁵Clinical Development Department, Daiichi Sankyo RD Novare Co., Ltd., 1-16-13, Kitakasai, Edogawa-ku, Tokyo 134-8630, Japan

⁶Pain & Neuroscience Laboratories, R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan

⁷Biomarker Department, Oncology Function, R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan

⁸Department of Cardiology and Health Center, Keio University School of Medicine, Shinano-machi 35, Shinjuku-ku, Tokyo 160-8582, Japan

^*Corresponding Author: Natsumi Nishihama, Venture Science Laboratories, R&D Division , Daiichi Sankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan, Tel: +81-3-3492-3131, Fax: +81-3-5740-3641

Keywords: Heart failure; LC-MS/MS, Microarray; Lipid droplet; ER stress; Cellular metabolism

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