Journal of Glycobiology

Journal of Glycobiology
Open Access

ISSN: 2168-958X

+44 1478 350008

Short Communication - (2020)Volume 9, Issue 3


Gandla Nikitha*
*Correspondence: Gandla Nikitha, Department of Pharmaceutical Analysis, Gokaraju Rangaraju College of Pharmacy, India, Email:

Author info »

Short Communication

Glycobiology is the study of the structure, function and biology of carbohydrates, also called glycans. Glycans are present in every living organism. Glycobiology is a rapidly growing field in biology, with relevance to biomedicine, biotechnology and basic research.

Glycoengineering approaches create modern counter acting agent variations with altogether upgraded capacity to select resistant cells, like Characteristic Executioner (NK) cells, macrophages/monocytes and neutrophils. By planning and controlling the sort of sugar atoms in a particular locale of the counter acting agent, the liking of the counter acting agent for resistant effector cells is expanded.This allows more effective antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (ADCP) and thus the capacity of a targeted antibody to trigger the death of cancerous cells. The primary item based on the glycoengineering innovation has recently entered the market.

The carbohydrate components of glycoproteins are known to influence the structure and work of glycoproteins, and hence it is critical to create compelling apparatuses to control and optimize the glycan components of glycoproteins with therapeutic significance.

Antibody, also called immunoglobulin, a defensive protein delivered by the safe framework in reaction to the nearness of a remote substance, called an antigen. Antibodies recognize and hook onto antigens in arrange to evacuate them from the body. A wide run of substances are regarded by the body as antigens, counting disease-causing life forms and poisonous materials such as insect poison.

Antibodies are assembled into five classes concurring to their steady locale. Each lesson is assigned by a letter joined to an abbreviation of the word immunoglobulin: IgG, IgM, IgA, IgD, and IgE. The classes of counter acting agent contrast not as it were in their consistent locale but moreover in action. For case, IgG, the foremost common antibody, is show generally within the blood and tissue liquids, whereas IgA is found within the mucous films lining the respiratory and gastrointestinal tracts.

Preformed antibodies, which are determined from the blood serum of already tainted individuals or creatures, are regularly managed in an antiserum to another individual in arrange to supply prompt, inactive immunization against fast-acting poisons or organisms, such as those in snakebites or lockjaw contaminations.

Antibodies are immunoglobulins that play essential roles in immune systems. All antibodies are glycoproteins that carry atleast one or more preserved N-linked oligosaccharides (N- glycans) at the Fc domain. Many studies have demonstrated that both the presence and fine structures of the attached glycans can exert a profound impact on the biological functions and therapeutic efficacy of antibodies. However, antibodies more often than not exist as blends of heterogeneous glycoforms that are troublesome to partitioned in unadulterated glycoforms. Later advance in glycoengineering has given valuable strategies that empower generation of glycan-defined and site-selectively adjusted antibodies for utilitarian considers and for made strides restorative adequacy. This audit highlights major approaches in glycoengineering of antibodies with a center on later propels in three zones: glycoengineering through glycan biosynthetic pathway control, glycoengineering through in vitro chemoenzymatic glycan remodeling, and glycoengineering of antibodies for site-specific antibody-drug conjugation.

Author Info

Gandla Nikitha*
Department of Pharmaceutical Analysis, Gokaraju Rangaraju College of Pharmacy, Hyderabad, India

Citation: Nikitha G, (2020) Glycoengineering. J. Glycobiol. 9:144. doi: 10.4172/2168-958X.20.9.144

Received: 01-Aug-2020 Accepted: 07-Aug-2020 Published: 14-Aug-2020 , DOI: 10.35248/2168-958X.20.9.144

Copyright: © 2020 Nikitha G. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.