Double β-alanine Substitutions Incorporated in 12-ring Pyrrole-Imidazole
Polyamides for Lengthened DNA Minor Groove Recognition

Takayoshi Watanabe¹, Ken-ichi Shinohara^1,2, Yoshinao Shinozaki¹, Syota Uekusa³, Xiaofei Wang¹, Nobuko Koshikawa¹, Kiriko Hiraoka¹, Takahiro Inoue¹, Jason Lin¹, Toshikazu Bando⁴, Hiroshi Sugiyama^4,5 and Hiroki Nagase^1*

¹Laboratory of Cancer Genetics, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba, 260-8717, Japan, E-mail: sakizuki@chiba-cc.jp

²Department of Molecular Oncology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuoh-ku, Chiba, 260-8617, Japan, E-mail: sakizuki@chiba-cc.jp

³Department of Pediatric Surgery, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi-Ku, Tokyo, 173-8610, Japan, E-mail: sakizuki@chiba-cc.jp

⁴Department of Chemistry, Faculty of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto, 606-8502, Japan, E-mail: sakizuki@chiba-cc.jp

⁵Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Yoshida Honmachi, Sakyo, Kyoto, 606-8501, Japan, E-mail: sakizuki@chiba-cc.jp

^*Corresponding Author: Hiroki Nagase, Laboratory of Cancer Genetics, Chiba Cancer Center Research Institute, 666-2 Nitona, Chuoh-ku, Chiba, 260-8717, Japan, Fax: 81432638175 Email: