An Integrated Computational and Experimental Binding Study Identifies the DNA Binding Domain as the Putative Binding Site of Novel Pyrimidinetrione Signal Transducer and Activator of Transcription 3 (STAT3) Inhibitors

Shan Sun^1,3, Peibin Yue², Mingzhu He³, Xiaolei Zhang², David Paladino², Yousef Al-Abed³, James Turkson^2* and John K Buolamwini^1,4*

¹Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 847 Monroe Avenue, Suite 327, Memphis, TN 38163, USA, E-mail: john.buolamwini@rosalindfranklin.edu

²University of Hawaii Cancer Center, Cancer Biology and Natural Products and Experimental Therapeutic Programs, 701 Ilalo Street, Suite 344, Honolulu, HI 96813, USA, E-mail: john.buolamwini@rosalindfranklin.edu

³Center for Molecular Innovation, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY11030, USA, E-mail: john.buolamwini@rosalindfranklin.edu

⁴Department of Pharmaceutical Sciences, College of Pharmacy, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, USA, E-mail: john.buolamwini@rosalindfranklin.edu

^*Corresponding Author(s): James Turkson, University of Hawaii Cancer Center, Cancer Biology and Natural Products and Experimental Therapeutic Programs, 01 Ilalo Street, Suite 344, Honolulu, HI 96813, United States of America, Tel: 808-356-5784 Email: John K Buolamwini, Department of Pharmaceutical Sciences, College of Pharmacy, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064, United States, Tel: 847-578-8341 Email: