Activation of Hypoxia-Inducible Factor by Di-Methyl Oxalyl Glycine (DMOG) Increases Neovascularization within Ischaemic Myocardium in a Porcine Coronary Artery Occlusion Model

Kelly DJ^1,2, Morton AC¹, Arnold ND¹, Mecinovic J³, Schofield C³, Lupton H⁴, Al-Lamee K⁵, Crossman DC¹, Julian Gunn^1*# and Gershlick A^2#

¹Department of Cardiovascular Science, University of Sheffield, Sheffield, UK

²Department of Cardiology, Glenfield General Hospital, Leicester, UK

³Chemistry Research Laboratory, University of Oxford, UK

⁴Brivant Ltd, Galway, Ireland

⁵Lombard Medical Technologies PLC, UK

^#Contributed equally to this work

^*Corresponding Author: Dr. Julian Gunn, Department of Cardiovascular Science, Faculty of Medicine, University of Sheffield, Room M116, Medical School, Beech Hill Road, Sheffield S10 2RX, UK, Tel: 0044 114 226 1432 Email: