Modern Chemistry & Applications

Modern Chemistry & Applications
Open Access

ISSN: 2329-6798


Sathiyanarayanan Lohidasan

Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth Deemed to be University (BVDU), Pune 411038, India

  • Research Article   
    Pharmacokinetic and Pharmacodynamic Interaction of Andrographolide with Meloxicam in Wistar Rats
    Author(s): Mythili Srinivasan, Sathiyanarayanan Lohidasan, Arulmozhi Sinnathambi and Kakasaheb Mahadik*

    Aim of the study: The primary aim of this study was to evaluate the possible pharmacokinetic and pharmacodynamics (anti-inflammatory) herb-drug interaction of Andrographolide (AN) with meloxicam (Melx) in Wistar rats. Materials and methods: A sensitive and validated RP-HPLC method was developed for the simultaneous estimation of AN and Melx in rat plasma. The oral administration of AN (60mg/kg), Melx 1.55mg/kg) and co-admin group in male-Wistar rats were given. The plasma drug concentration was evaluated using the RP-HPLC method and the pharmacokinetic parameters such as Cmax, Tmax, MRT, T½, CL, Vd, and AUC were calculated. Pharmacodynamic parameters such as Change in paw volume, mechanical hyperalgesia, and mechanical nociceptive threshold were evaluated for predicting the herb-drug interaction. Results:.. Read More»

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