Journal of Clinical Toxicology

Journal of Clinical Toxicology
Open Access

ISSN: 2161-0495

Sara Toulouie

California North state University College of Medicine, University of California, Santa Barbara, USA

  • Case Report   
    Massive Bupropion and Oxcarbazepine Overdose
    Author(s): Abha Sathe, Anna Thiemann, Sara Toulouie* and Edward Durant

    Context: To describe a case of massive bupropion overdose leading to cardiac toxicity and seizures in an adolescent suicide. Case: A 19 year old female presented to the emergency department with an estimated bupropion overdose of 28.2 grams with possible oxcarbazepine consumption. The patient was unresponsive and was treated for intermittent seizures and cardiogenic shock but could not be resuscitated and died within 48 hours. Discussion: Several existing reports regarding bupropion overdose describe sinus tachycardia and seizures corrected by symptomatic treatment. However, to our knowledge, this case documents the highest ingestion of bupropion recorded thus far in literature and demonstrates the rapid onset of cardiac dysfunction... Read More»

    Abstract PDF