Journal of Vaccines & Vaccination

Department of Medicine, The University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States

Publications

• Review Article   
  GM-CSF: Anti-Cancer Immune Response and Therapeutic Application
  Author(s): Susan Morand, Monika Devanaboyina, Courtney Fung, Rachel Royfman, Louis Filipiak, Laura Stanbery, Danae Hamouda and John Nemunaitis*
  
  A primary focus of cancer therapeutics today is precision, or target directed, therapy. Combination treatment with precision therapy can involve both immune and signal pathway targets. One approach involving the chemokine GMCSF involves enhancement of the immune system. Herein is a review of the literature and the current therapeutic role of GM-CSF, including the proposed immune mechanisms and potential applications of GM-CSF to enhance anticancer immunotherapy. GM-CSF’s potent effects on dendritic cell activation and subsequent stimulation of T-lymphocyte activity make it an attractive potential addition to combination therapeutic regimens, including radiation therapy, oncolytic viral therapy, immune checkpoint inhibition, and autologous tumor vaccines, and warrants further clinical exploration, with an emphasis on identifying concomitant molecular pathways that mediate resista.. View more»
  

  DOI: 10.35248/2157-7560.21.S10.002

  Abstract HTML PDF