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Muruganandam M
Department of Einsteein Bio-Engineering Research Foundation, Tamil Nadu, India
Publications
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Review
Bacterial Plasmid DNA Enhances the Efficacy of Vaccine and their Advantages in Vaccine Development
Author(s): Muruganandam M*
Many Bacterial components used as immunogen during vaccine development. Plasmid DNA is one among them. It is a short sequence DNA. It always carries one or more genes responsible for useful characteristics. If use DNA in vaccine development, it is more practical and less expensive. It has resistance to temperature extremes, Storage and transport is also easy. DNA vaccines provides long term immunity. The plasmid DNA induces humoral antibodies and cell mediated immunity against bacterial pathogens. In our studies proved that naked plasmid DNA and mutant pathogens plasmid DNA acted as good immunogens. The single and double enzyme digested plasmid DNA also produces good immune responses in many cases. The mixer of plasmid DNA of pathogenic bacteria also produces good immunity which is help to prepare. Mixer vaccines against more than one diseases and plasmid DNA companied with antigenic .. View more»