Pharmaceutica Analytica Acta

Department of Pharmaceutical Chemistry, Ashur University College, Iraq

Publications

• Research Article   
  In Silico Design, Synthesis and Characterization of New Spebrutinib Analogues
  Author(s): Zaid M Jaber Al-Obaidi*, Omar F Abdul-Rasheed, Monther F Mahdi and Ayad MR Raauf
  
  Background: Recently, in silico or computer-aided drug design has emerged as a cornerstone on the harbor of modern drug discovery. One of the approaches to treat cancer is the inhibition of tyrosine kinase, which is considered as a key enzyme in the survival of the cancerous cells. Spebrutinib, as a member of the tyrosine kinase inhibitors, has few unwanted side effects due to its off-target bindings. In this work, the GOLD program was employed to predict the bindings and thus the inhibitory activity toward the tyrosine kinase. Methodology: After the design and docking processes, the chemical synthesis of three spebrutinib analogues was achieved. Results: The percent yields of the chemical syntheses were ranged from 81% to 89%. These analogues were characterized utilizing; FT-IR, DSC, CHN, and 1H NMR. In conclusion.. View more»
  

  DOI: 10.35248/2153-2435.19.10.612

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