Journal of Vascular Medicine & Surgery

Journal of Vascular Medicine & Surgery
Open Access

ISSN: 2329-6925

Marilyn J. Cipolla

Department of Neurological Sciences, University of Vermont Larner College of Medicine, Burlington, VT, USA

  • Mini Review   
    Aging-Related Structural and Functional Changes in Cerebral Arteries: Caloric Restriction (CR) Intervention
    Author(s): Maurizio Mandalà* and Marilyn J. Cipolla

    Cerebral arteries play a crucial role in the regulation of blood flow to the brain to satisfy the demand of oxygen and glucose for proper function of the organ. Physiological cerebral blood flow (CBF) is maintained within a normal range in response to changes in blood pressure a mechanism named Cerebral Blood Flow Auto Regulation (CBFAR). Structure and function of cerebral arteries have an important impact on CBFAR. Several studies in human and animals have showed significant morphological and functional changes in cerebral vessels of aged brain associated with a reduced CBF which is also impaired in cerebrovascular pathology linked to brain diseases. Interestingly, one new emergent aspect is the lifelong Calorie Restriction (CR) as a potential intervention to prevent age-related cerebral artery changes and preserve the health of aging brain. This review summarizes the recent literatu.. Read More»
    DOI: 10.35248/2329-6925.21.s7.002

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