Advances in Pediatric Research
Open Access

Department Pediatric Endocrinology, Regina Margherita Children Hospital, University of Turin, Turin, Italy

Publications

• Research Article   
  Growth Evaluation in Silver Russel Syndrome and Small Gestational Age Patients Exposed to GH Treatment: A Mathematical Approach
  Author(s): Giuseppe Migliaretti*, Ilaria Stura, Francesca Maria Brondino, Patrizia Matarazzo and Luisa De Sanctis
  
  Objective: The study proposes a description and a mathematical model of growth of both Silver Russell Syndrome (SRS) and Small for Gestational Age (SGA) patients, with and without Growth Hormone (GH) treatment. Design and methods: Thirteen patients with molecular diagnosis of SRS were compared with 13 sex-paired SGA subjects. For each patient, neonatal and follow up auxological data were collected. A predictive growth model based on the gompertzian function and optimization method, already tested and validated on a cohort of GH-deficient children, was used. Results: Baselines anthropometric values do not significantly differ between the presented SRS and SGA populations. The applied mathematical model showed same natural growth hope for SGA and SRS subjects. In SRS patients under GH treatment a significant i.. Read More»
  DOI: 10.35248/2385-4529.23.10.050

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