Clinical & Medical Biochemistry

Faculty of Science, Department of Chemistry, Kanagawa University, Tsuchiya, Hiratsuka, Kanagawa 259-1293, Japan

Publications

• Mini Review Article   
  Physicochemical Cause and Effect Observed in DNA Length-Dependent Division of Protocell as the Primitive Flow of Information
  Author(s): Muneyuki Matsuo, Kensuke Kurihara, Taro Toyota, Kentaro Suzuki and Tadashi Sugawara*
  
  In the prebiotic era, physicochemical cause and effect served as the primitive flow of information for protocells. Our recent study claimed that the manners and frequencies of self-reproduction of giant vesicle (GV) -based model protocells were regulated by the incorporated DNA-length, and not the base-pair sequence due to the presence of a supramolecular catalyst (lipo-deoxyribozyme) composed of DNA and lipophilic catalysts. The DNA-length dependent dynamics of the self-reproducing GVs containing different length of DNA were examined by three independent experiments; Population analysis by flow cytometric measurements, counting of???increased numbers of protocells and direct morphological observation of a single GV by confocal microscopy. These results may shed light on the information system in the prebiotic stage, when the central dogma was not established. Notably, recent r.. View more»
  

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