Journal of Allergy & Therapy

Journal of Allergy & Therapy
Open Access

ISSN: 2155-6121

Inderpal Randhawa

Pediatric Pulmonology/Allergy/Immunology, Miller Children’s Hospital, 2801 Atlantic Avenue, Long Beach, California, 90806, USA

  • Research Article   
    Tolerance Induction Program Effect Explains Variation in Wheal Size, sIgE, and IgG4 in Peanut Allergic Children
    Author(s): Inderpal Randhawa*

    Background: Tolerance induction oral immunotherapy, unique to our centre and termed the Tolerance Induction Program (TIP), has shown promise as a safe form of treatment in peanut allergic children. Evaluations of emerging treatments for peanut allergy typically report from a population average perspective. Our study sought to compare rate of decline in peanut-skin prick testing wheal size and sIgE following one year of high dose, weekly peanut immunotherapy using the standard population average approach to findings that account for subject variation in intercepts and slopes. Methods: This is a descriptive study in 51 peanut allergic children who underwent TIP at the Translational Pulmonary and Immunology Research Centre in Long Beach, California. Post intervention reductions in peanutwheal size and sIgE were assessed using Wilcoxen signed rank test and mixed effects modelling p.. Read More»

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