Immunotherapy: Open Access

Immunotherapy: Open Access
Open Access

ISSN: 2471-9552

+44 1223 790975

Gabriel Kotak

Department of Biomedical Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK

  • Short Communication   
    T-cell Immunity in Children after Rotavirus Infection
    Author(s): Gabriel Kotak*

    In children, cellular immunity against rotavirus is poorly known. The present state of knowledge about T-cell immunity to rotavirus in children is described in this. Rotavirus-specific T-cell immunity develops and broadens responsiveness in children as they get older. T-cell responses are more temporary than antibody responses, although they can happen even when there are no measurable antibody responses. Rotavirus-induced T-cell immunity is primarily gut homing, involving Th1 and cytotoxic subsets that may be modulated by IL-10 Tregs. In compared to other infectious pathogens and adults, however, rotavirus-specific T-cell responses in children are often modest in frequency in peripheral blood. The available research on the T-cell immune response in children is summarised here. Rotavirus-specific T-cell responses have protective correlations against infection or va.. View More»
    DOI: 10.35248/2471-9552.22 .08.187

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