Clinical & Medical Biochemistry

Department of Biochemistry, Tanzania Food and Nutrition Center, Dar es Salaam, Tanzania

Publications

• Original Research Article   
  Human Leukocyte HLA-B7 and HLA-B27 Antigen Typing among Healthy Adults Primedwith HIV-1 DNA Boosted with Recombinant Modified Vaccinia Ankara in Dar Es Salaam
  Author(s): Francis Millinga* and Cyprian Mpinda
  
  Background: The human leukocyte antigens are genetically inherited proteins present on thesurface of the cells of the immune system. Cells of the immune system recognize antigens only when presented to them next to an MHC self-molecule. Three main types of HLA Class I namely, HLA-A, HLA-B and HLA-C they are expressed by most human cells. Class I HLAs are involved in discriminating and presenting antigens to T-lymphocytes. T-lymphocytes kill the cell presenting it. T-lymphocytes destroy cells infected together with viruses, including HIV. Developing a vaccine for HIV may be aided by a complete understanding of those rare cases in which some HIV-infected individuals control replication of the virus. Most of these elite controllers express the histocompatibility alleles HLA-B57 or HLA-B27, these alleles remain the most robust associations with low conc.. View more»
  

  DOI: 10.35248/2471-2663.19.6.149

  Abstract HTML PDF