Journal of Cell Science & Therapy
Open Access

Department of Pediatrics, Affiliate of Columbia University, Harlem Hospital Center, New York, NY 10037, USA

Publications

• Research Article   
  13C of testosterone Affecting Breast,Ovarian , and Endometrial Cancer Cells
  Author(s): Mengqi Zhang, Xinchen Wu*, Wenning Yang* and Rui Yang
  
  Stable heavy isotopes of bio-elements have potential biological activities which is an issue being neglected. The enrichment of heavy isotope in the molecule of a substance may alter the substance’s effects on organism. In our study, the enrichment level of heavy carbon isotope (13C) in testosterone reached to the isotopic ratio (13C/12C) of 9.78%, by which heavy carbon testosterone was produced. The human cancer cells of breast (MCF-7), ovarian (SK-OV-3), and endometrial (Ishikawa) were exposed to testosterone and heavy carbon testosterone (named 13C enriched testosterone) respectively. The growth and morphology of the cells were studied. The dose impact of the compound was investigated as well. To the best of our knowledge, this is the first study demonstrating the influence of heavy carbon isotope on cancer cell.. View More»
  DOI: 10.35248/2157-7013.22.14.376

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