Biochemistry and Pharmacology Program, Federal University of Espirito Santo, Vitoria, ES, Brazil
The CXCR2-SNAIL Axis: Is this a Novel Anti-Tumor Therapeutical Target for Cancer Cells Undergoing Epithelial-Mesenchimal Transition Process?
Author(s): Taciane Barbosa Henriques, Diandra Zipinotti dos Santos, Mariam F. Hakeem-Sanni, Ian Victor Silva and Leticia Batista Azevedo Rangel*
The epithelial-mesenchymal transition (EMT) plays an important role in the progression of cancer, metastasis and drug resistance. Several factors are known to mediate EMT-driven drug resistance in cancer cells, among them the tumor microenvironment (TME). This phenomenon has gained attention in the field of cancer biology for its potential contribution to in the progression of carcinomas. It is also known that tumor cells experiencing EMT increases the secretion of specific factors in the TME, including cytokines, chemokines and growth factors, which can play an important role in tumor progression. The main event in EMT is the repression of E-cadherin driven by transcriptional factors including SNAIL, SLUG and ZEB1. Chemokines function as growth factors, activating, through its receptor CXCR2 and transcription factors such as SNAIL, thus inducing the EMT phenotype, contributing to the.. Read More»