Pharmaceutica Analytica Acta

Department of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, Iraq

Publications

• Research Article   
  Molecular Docking Studies for Design, Synthesis and Characterization of New Imatinib Analogues
  Author(s): Ali Naim Hussein, Omar F Abdul- Rasheed*, Monther F Mahdi and Ayad MR Raauf
  
  Background: In silico drug design conducts a process for making conformations and directions of multiple ligands and chooses the best ones, then being selected. In silico studies are used to examine and model molecular interactions between target macromolecules and ligand. Tyrosine kinase is considered a potential target to design inhibitors. Tyrosine kinase inhibitor like imatinib this drug has succeeded to pass through clinical studies in an attempt to cure the cancer, which is considered as the second leading cause of deaths in the world. In this work, the GOLD program was employed to predict the bindings and thus the inhibitory activity toward the tyrosine kinase. Methodology: After the design and docking processes, the chemical synthesis of three imatinib analogues was achieved. Results: the percent of yield of th.. View more»
  

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