William M Hague
Australia
Research Article
Predictors of Preeclampsia in Women in the Metformin in Gestational Diabetes(Mig) Study
Author(s): Helen L Barrett, Marloes Dekker Nitert, H David McIntyre, William M Hague, Leonie K Callaway and Janet RowanHelen L Barrett, Marloes Dekker Nitert, H David McIntyre, William M Hague, Leonie K Callaway and Janet Rowan
Background: Gestational Diabetes Mellitus (GDM), maternal obesity and pregnancy weight gain are associated with an increased risk of developing Preeclampsia (PE). The aim of this study was to examine the predictors of PE in women commencing pharmacotherapy for GDM in the Metformin in Gestational diabetes trial.
Methods: Descriptive and logistic regression analyses examined the relationship between maternal enrolment characteristics and later development of PE.
Results: 46 (6.3%) of 703 women developed PE. At enrolment ((30 (SD3.2) weeks gestation), women who later developed PE had higher HbA1c (6.14% (95%CI 5.84, 6.45) vs. 5.73% (95%CI 5.67, 5.78), P=0.003), fasting triglycerides (2.93 mmol/L (95%CI 2.57, 3.29) vs. 2.55mmol/L (95%CI 2.47, 2.62), P=0.03) and blood pressure. Their infants were born 9 days earlier (P&.. View More»
