Dentistry

Wei Li

Publications

• Research Article
  Preliminary 1H NMR-based Metabolomics Analysis to Explore The Link Between SrtA Function and Cariogenicity of S.mutans
  
  Author(s): Ying Song, Jian Zhang, Chuanyong Wang, Wei Li, Jinglin Zhou and Ling ZouYing Song, Jian Zhang, Chuanyong Wang, Wei Li, Jinglin Zhou and Ling Zou
  
  Objectives: Streptococcus mutans is the major pathogen associated with caries, and its adhesion to tooth surfaces is the first step in cariogenesis. Sortase A (SrtA) is a key enzyme responsible for anchoring proteins in the cell wall; deleting the gene reduces the cariogenicity of the pathogen. To gain insight into how SrtA supports cariogenicity, we performed a metabonomics study based on 1H nuclear magnetic resonance in which we compared extracellular metabolites of wild-type S. mutans UA159 and a SrtA-deficient strain. Methods: Metabolite differences between strains were identified using a combination of principal component analysis and orthogonality partial least squares discriminant analysis. Results: Several differences were identified, corresponding mostly to unknown metabolites. Some amino acids such as leu.. View More»
  DOI: 10.4172/2161-1122.1000418

  Abstract