Vijay Kumar Singh
India
Research Article
Caenorhabditis elegans Model to Test the Effect of Pharmacological Drugs on IGF-1/insulin Signalling Pathway
Author(s): Jitendra Kumar, Anjali Awasthi, Kyung-Chae Park, Vijay Kumar Singh and Birendra PrasadJitendra Kumar, Anjali Awasthi, Kyung-Chae Park, Vijay Kumar Singh and Birendra Prasad
Many pharmacological drugs have been reported to alter insulin signalling in the body resulting in altered blood glucose levels. Drug induced hypoglycaemic or hyperglycaemic effect may lead to adverse effects especially in diabetic patients. Treating ailments of diabetic patients has always remained challenging for the clinicians due to unexplored effect of many drugs on insulin signalling. Insulin/insulin like growth factor-1 signalling (IIS) pathway is highly conserved between Caenorhabditis elegans and humans. In both C. elegans and humans IIS pathway is involved in regulating fat storage. C. elegans dauer formation is regulated primarily via IIS pathway and is triggered by adverse environmental conditions. In this paper we proposed the use of C. elegans dauer formation as a vital strategy to check the drug interaction with IIS. Activity of DAF-2 a.. View More»
