Journal of Stem Cell Research & Therapy

Tomonari Kasai

Publications

• Research Article
  Hyaluronic Acid Mediated Enrichment of CD44 Expressing Glioblastoma Stem Cells in U251MG Xenograft Mouse Model
  Author(s): Arun Vaidyanath, Hafizah Binti Mahmud, Apriliana Cahya Khayrani, Aung KoKo Oo, Akimasa Seno, Mami Asakura, Tomonari Kasai and Masaharu SenoArun Vaidyanath, Hafizah Binti Mahmud, Apriliana Cahya Khayrani, Aung KoKo Oo, Akimasa Seno, Mami Asakura, Tomonari Kasai and Masaharu Seno
  
  Background: Glioblastoma is one of the most aggressive cancer with high mortality rates and poses several hurdles in the efficient chemotherapeutic intervention. Similar to other cancers, glioma also harbors CSCs, that are self-renewable, multipotent cells, which initiate the cancer incidence, chemotherapeutic resistance and cancer recurrence. The microenvironmental regulation in the brain tumor and metastasis involves the cooperative interaction between HA and CD44. CD44, being a multifaceted transmembrane glycoprotein by itself, or in combination with several other cell surface receptors, has been used as a marker for CSC isolation. Methods: We established both adherent and nonadherent culture of U251MG cells by treating with high molecular weight HA. Further these cells were transplanted subcutaneously in Balb/c mouse for the generation o.. View More»
  DOI: 10.4172/2157-7633.1000384

  Abstract PDF