Timothy W Garvey
Tanzania
Research Article
Impact of Major Depressive Disorder on Prediabetes by Impairing Insulin Sensitivity
Author(s): Li Li, Richard Charles Shelton, USA Chassan, John Charles Hammond, Barbara Ann Gower and Timothy W GarveyLi Li, Richard Charles Shelton, USA Chassan, John Charles Hammond, Barbara Ann Gower and Timothy W Garvey
Reports regarding the associations between major depressive disorder (MDD) and diabetes remain heterogeneous. Our aim was to investigate whether glucose homeostasis and insulin sensitivity were impaired in the MDD patients and its mechanisms. A total of 30 patients with MDD and 30 matched controls were recruited. The oral glucose tolerance test and dual-energy X-ray absorptiometry scan were performed in each participant. Insulin signaling in postmortem brain tissues from other depressive patients and controls (obtained from Alabama brain bank) was examined. Insulin sensitivity was reduced substantially in the MDD patients, however, the fasting and 2-h glucose concentrations remained within the normal range through compensatory insulin secretion. Despite increased insulin secretion, 1-h glucose concentrations in the MDD patients were significantly elev.. View More»
