Journal of Clinical & Experimental Pharmacology

Shimada Y

Publications

• Research Article
  Anti-cancer Effect in Volatile Components of Hiba Essential Oil (Thujopsis dolabrata)
  Author(s): Nagata T, Fujino Y, Toume K, Xiao Long L, Yamaguchi T, Okumura T, Komatsu K and Shimada YNagata T, Fujino Y, Toume K, Xiao Long L, Yamaguchi T, Okumura T, Komatsu K and Shimada Y
  
  Objective: Although combinations of multiple cancer therapies have reduced the mortality, they often cause severe adverse reactions, and the new strategies with fewer adverse reactions are desired. Our present study demonstrated that an essential oil preparation from hiba (Thujopsis dolabrata) exerts an antitumor effect against gastric cancer cells. Methods: MKN45 gastric cancer cells were incubated with whole of hiba essential oil (HEO) or volatile components of the HEO, followed by assessment of tumor growth inhibition by MTT assay. Apoptotic change of these cancer cells was also analyzed by TUNEL reaction. Nude mice were used to establish a model of gastric cancer tumor growth and peritoneal disseminated metastasis, in which the volume of tumor and the number of pe.. View More»
  DOI: 10.4172/2161-1459.1000214

  Abstract PDF