Saranpal Singh
India
Research Article
Ameliorative Effect of Lycopene on Lipid Peroxidation and Certain Antioxidant Enzymes in Diabetic Patients
Author(s): Kuldip Singh, Bal BS, Seema Chopra, Saranpal Singh and Naresh MalhotraKuldip Singh, Bal BS, Seema Chopra, Saranpal Singh and Naresh Malhotra
Objectives: To study the ameliorative properties of lycopene in diabetic patients by measuring oxidative stress biomarkers such as malondialdehyde (MDA), antioxidant enzymes like xanthine oxidase (XOD), superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and low molecular weight antioxidant compound that is reduced glutathione (GSH) in diabetic patients. Materials and Methods: The subjects were divided into three groups: Group-1: Normal healthy subjects (Control); Group- 2: Diabetic patients and Group- 3: 4 mg lycopene ingested diabetic patients. The levels of MDA, XOD, SOD, GPx, GR and GSH were determined in blood samples in all the groups for evaluation of oxidant– antioxidant status. Results: A significant (p<0.001) elevation in MDA and XOD levels while a significant (p<0.01) reduction in SOD, GPx, GR and GSH levels was observed in diabe.. View More»
