Journal of Liver

Rodriguez Fragoso L

Publications

• Research Article
  Genistein Produces Hepatoprotection through Modulating EGFR Expression and Phosphorylation in Experimental Fibrosis
  Author(s): Rodriguez Fragoso L, Alvarez Ayala E, García Vazquez F and Reyes Esparza JRodriguez Fragoso L, Alvarez Ayala E, García Vazquez F and Reyes Esparza J
  
  Background and Objective: Liver disease chronicity leads to the appearance of fibrosis, cirrhosis, and eventually cancer. For this reason, it is important to research new fibrosis therapies. The use of genistein as a hepatoprotective agent has been studied, but its mechanism of action is unknown. The aim of this work was to evaluate the role of genistein as a fibrosis treatment and its possible mechanism of action through CCl4-induced inhibition of EGFR in rat specimens. Methods: Hepatic fibrosis was brought about by chronic administration of CCl4 to rats. Animals with fibrosis were treated with 1 mg/kg genistein. To evaluate the hepatoprotection of genistein on liver fibrosis, we made a histopathological analysis using both H&E and trichrome staining, as well as an immunofluorescence analysis for α- SMA and an immunohistochemical analysis for PCNA. In order to find out the .. View More»
  DOI: 10.4172/2167-0889.1000196

  Abstract PDF