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Renati Damodar
Renati Damodar
Vignan Institute of Pharmaceutical Technology,
Besides VSEZ, Duvvada, Visakhapatnam-530046, Andhra Pradesh
India
Publications
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Research Article
Preparation and In-vitro Evaluation of Metformin HCl Tablets Containing Sustained Release Beads for Increasing Therapeutic Window
Author(s): Renati DamodarRenati Damodar
The purpose of present investigation was to develop the dosage form containing metformin for both immediate and sustained release. The SR release tablets of metformin were not useful to control the fasting glucose levels whereas conventional metformin tablets cannot acts for prolonged time, But the tablets prepared by present method useful for control both fasting glucose levels and maintenance dose. Even though many combination therapies available in market as metformin for sustain release and other sulfonylureas for immediate release, The primary concern for considering metformin hydrochloride as monotherapy was its efficient activity, less cost and negligible cardiac risk factors. The immediate release dose was developed by direct compression method and sustained release beads were prepared by inotropic gelation method using sodium alginate and sodium CMC, CaCl2. The various batche.. View More»
DOI: 10.4172/jbb.10000187