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Ramesh Bhonde
Ramesh Bhonde
India
Publications
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Research Article
Pluripotent Stem Cell within the Prostate could be Responsible for Benign Prostate Hyperplasia in Human
Author(s): Akhilesh Prajapati, Sharad Gupta, Ramesh Bhonde and Sarita GuptaAkhilesh Prajapati, Sharad Gupta, Ramesh Bhonde and Sarita Gupta
Aim: Abnormal prostate growth is the most prevalent pathological sign in aged human males, reflected by high incidence of Benign Prostatic Hyperplasia (BPH) and Prostate Cancer (PCa). The successful isolation and cultivation of prostate cells, is a prerequisite need for establishing model cell line for understanding the pathogenesis, unique biological properties and also various evidences suggest role of stem cells in pathogenesis of these conditions for therapeutic point of view. Methods and results: Here we isolate a candidate pluripotent stem cell population from BPH patients underwent TURP which include the isolation of an enriched population of prostate stem cells through cell culture techniques and the cultivation of prostate stem cells in vitro and characterization of these cells and their stem potential, including in-vivo teratoma generation. Cytogenetic analysis by G-banding .. View More»
DOI: 10.4172/2157-7633.1000164