Gerontology & Geriatric Research

Radhakrishna Para

Publications

• Research Article
  Age-Associated Alterations of Morphology and ProteinSignaling in the Female F344xBN Rat Aorta
  Author(s): Kevin M Rice, Jacqueline Fannin, Radhakrishna Para, Srinivasarao Thulluri, WilliamTriest, Paulete Wehner and Eric R BloughKevin M Rice, Jacqueline Fannin, Radhakrishna Para, Srinivasarao Thulluri, WilliamTriest, Paulete Wehner and Eric R Blough
  
  The Fischer 344 x Brown Norway F1 (F344xBN) male rat has been shown to undergo many of the same age-associated vascular changes seen in humans [1]. However, limited research has been done to determine if the female F344xBN rat is a good aging female rodent model to study age-associated changes in the vasculature. Previously we reported cardiac increases in oxidative-nitrosative stress and mitochondrial-mediated apoptosis in this model [2]. Aortae from 6-, 26-, and 30-month female F344xBN rats were stained with hematoxylin and eosin, and a trichrome stain to determine intima-medial thickness and fibrosis, respectively. Age-associated changes in expression and phosphorylation of proteins were measured by immunoblotting. Aging in the female F344xBN rat was associated with an increase in aortic intima-medial thickness, activation of p44/42 MAPK, and Hsp27 expression and decreased activati.. View More»
  DOI: 10.4172/2167-7182.1000196

  Abstract PDF