Biochemistry & Analytical Biochemistry

Prashanthkumar MV

Publications

• Research Article
  Analysis of the Cytotoxic Effects of Vitamin D3 on Colorectal, Breast and Cervical Carcinoma Cell Lines
  Author(s): Shruthi N, Prashanthkumar MV, Venugopalreddy B, Suma MN and Subba Rao VMShruthi N, Prashanthkumar MV, Venugopalreddy B, Suma MN and Subba Rao VM
  
  Although evidences from epidemiological suggested possible involvement of vitamin D in the prevention and treatment of cancers, it is not fully known how vitamin D inhibits cancer cell growth. Recent studies have shown that 1,25-(OH)2D inhibits cancer cell proliferation by binding to vitamin-D receptor (VDR). The vitamin D - VDR complex in turn (a) upregulate cell cycle inhibitors p21 and p27; (b) promote apoptosis mediators caspase-3 and 7, Bad, p53 and PTEN; (c) arrest cells in senescence phase; (d) elevate cell differentiation; and (e) inhibit IGF signaling. Moreover, vitamin D reduces reactive oxygen species (ROS) there by prevents the progression of cancer cells. However, it is currently unknown whether vitamin D induced cancer cell death is mediated by its effect on ROS destroying Nrf2 signaling. In addition, it is also not known whether withdrawal of glucose improves the effica.. View More»
  DOI: 10.4172/2161-1009.1000318

  Abstract PDF