Journal of Clinical & Experimental Pharmacology

Palma Santiago

Publications

• Research Article
  Pharmacokinetic Assessment of Novel Controlled Release Formulations of Ricobendazole Intended for Oral Administration in Dogs
  Author(s): Dib Alicia, Paredes Alejandro, Eliópulos Natasha, Farías Cristina, Suárez Gonzalo, Aldrovandi Ariel, Palma Santiago, Allemandi Daniel, Lanusse Carlos and Sánchez Bruni SergioDib Alicia, Paredes Alejandro, Eliópulos Natasha, Farías Cristina, Suárez Gonzalo, Aldrovandi Ariel, Palma Santiago, Allemandi Daniel, Lanusse Carlos and Sánchez Bruni Sergio
  
  The aim of this study was to evaluate the influence of different matrices developers on the pharmacokinetic behavior of Ricobendazole (RBZ) controlled release (CR) formulations and test their correlation in vitro-in vivo, using one Albendazole (ABZ)-based and one RBZ-based immediate-release formulation as references. The main excipients used for CR formulations were Hydroxypropyl Methyl Cellulose, Cetyl Alcohol, Gelucire 50/02� and Alginic Acid. Pharmacotechnical quality control tests were successfully completed. Twelve parasite-free no pregnant dogs were randomly divided into six groups and received different treatments (single oral doses) using an incomplete block design (two phases) (n=4). Phase I: treatment "A" (ABZ-based immediate-release formulation [25 mg/kg]). Treatment "B" (RBZ-based immediate release formulation [20 mg/kg]) and treatments from "C" to "F" (CR formulations [20 mg.. View More»
  DOI: 10.4172/2161-1459.1000198

  Abstract PDF