Journal of Blood Disorders & Transfusion

Pallavi Madukuri

Publications

• Review Article
  Hemophagocytic Lymphohistiocytosis: A Review
  Author(s): Sirisha Rani Siddaiahgari, Shirali Agarwal, Pallavi Madukuri and Latha Subramanyam MoodahaduSirisha Rani Siddaiahgari, Shirali Agarwal, Pallavi Madukuri and Latha Subramanyam Moodahadu
  
  Hemophagocytic lymphohistiocytosis (HLH) is a disorder charecterised by immune dysregulation. Though it was underdiagnosed earlier now it is increasingly being diagnosed across the world with better awareness among physicians. “Hypercytokinemia” which is the hallmark of HLH can result in end organ damage and even death in some cases if there is delay in diagnosis. It has a wide array of presentation but commonly presents as fever with organomegaly and bicytopenia. A vast majority of cases are acquired due to secondary causes but primary HLH is also not uncommon which also intern gets triggered by infection as suggested by recent studies. Laboratory parameters like Ferritin, triglycerides and fibrinogen along with bicytopenia/pancytopernia aid in further confirmation of this diagnosis. Bone marrow may or may not show evidence of HLH, Hence absence of involvement should not .. View More»
  DOI: 10.4172/2155-9864.1000363

  Abstract PDF