Journal of Carcinogenesis & Mutagenesis

Orduña-Salazar AA

Publications

• Commentary
  Different Effects of the RNASEL R462Q Mutation on the Risk of Developing Prostate and Cervical Cancer in Latin American Subjects: A Meta-Analysis
  Author(s): Porchia ML, Meda E, Zepeda RC, Orduña-Salazar AA, Juárez-Salazar G, González-Mejia ME and Aguirre GPorchia ML, Meda E, Zepeda RC, Orduña-Salazar AA, Juárez-Salazar G, González-Mejia ME and Aguirre G
  
  Background: Prostate and cervical tissues are highly susceptible to carcinogenesis. Furthermore, some reports suggest that alterations in RNASEL have been associated with augmented risk of developing cancer, specifically the arginine to glutamine mutation at position 462 (R462Q). However, with conflicting results of the R462Q mutation on cancer risk, our goal was to determine what effect this mutation had on prostate and cervical cancers in Latin Americans. Methods: PubMed, EBSCO, SCOUPS, Wiley and OVID databases, and study bibliographies were systematically searched for case-control studies that examined for the R462Q mutation until June 2015. Odds ratios (ORs) and 95%CI were calculated from the genotype data. The pooled ORs were obtained by the Peto method for the heterozygous, the homozygous, the dominant, the recessive, and the allelic g.. View More»
  DOI: 10.4172/2157-2518.1000234

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