Journal of Clinical & Experimental Pharmacology

Omonkhelin J Owolabi

Publications

• Research Article
  Co-administration of glibenclamide and amlodipine induces resistance to hyperglycemic treatment in streptozotocin induced adapted/non adapted diabetic rats
  Author(s): Omonkhelin J Owolabi and Eric K I OmogbaiOmonkhelin J Owolabi and Eric K I Omogbai
  
  It is a well known fact that diabetes co-exist with hypertension. In fact studies have shown that about 65 % of diabetics have hypertension. Amlodipine, a calcium channel blocker is a well known anti-hypertensive frequently prescribed, even in diabetes. Potassium adaptation combined with amlodipine has also been shown to reduce blood pressure. This research is geared towards assessing the effects of both amlodipine and potassium adaptation on diabetic rats treated with glibenclamide. Diabetes was induced using streptozotocin in rats both potassium adapted and non-adapted, thereafter glibenclamide (5 mg/kg) alone and a combination of glibenclamide (5 mg/kg) and amlodipine (5 mg/kg) were administered orally. The animals were separately kept in metabolic cages and their urine volume, levels of plasma glucose, plasma and urine creatinine/ creatinine clearance, the lipid profile, plasma and u.. View More»
  DOI: 10.4172/2161-1459.1000102

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