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Nipun Mahajan
Nipun Mahajan
India
Publications
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Review Article
An Insight in to the Pathogenesis of Diabetic Vascular Diseases: Role of Oxidative Stress and Antioxidants
Author(s): Aditi, Nipun Mahajan, Shruti Rawal and Rajesh KatareAditi, Nipun Mahajan, Shruti Rawal and Rajesh Katare
The profound effects of hyperglycaemia on the vascular tree are the major causes of morbidity and mortality among patients suffering from diabetes. Diabetic Vascular Diseases (DVD) includes accelerated forms of atherosclerosis due to endothelial dysfunction and microangiopathy of retinal vessels. A host of several studies indicate that increased oxidative stress play a pivotal role in the development and progression of diabetic vascular diseases. The metabolic abnormalities due to oxidative stress are linked to the structural and functional changes in the vasculature, consequently resulting in atherosclerosis and diabetic retinopathy. Oxidative stress brings alterations in downstream transcription factors which result in changes in gene expression, myocardial substrate utilization, myocyte growth, endothelial function and myocardial compliance. Based on this, an approach towards investig.. View More»
DOI: 10.4172/2153-2435.1000273