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Nikhil Sharma
Nikhil Sharma
India
Publications
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Research Article
Motif Design for Nitrilases
Author(s): Nikhil Sharma and Tek Chand BhallaNikhil Sharma and Tek Chand Bhalla
Nitrilase is one of the nitrile metabolizing enzymes that catalyses the conversion of nitriles to corresponding acids which has gained importance in green chemistry. Nitrilase being substrate specific yet it acts over a wide range of nitriles (aliphatic/aromatic) has drawn attention due to its utility in mild hydrolysis. Most of the nitrilases reported hitherto have been physically extracted characterized from the microbial/plant sources. In order to identify sequences for nitrilases two groups of motif were designed i.e. aliphatic nitrilase motif’s (MDMAl) and aromatic nitrilase motif’s (MDMAr) each with four motifs specifically belonging to nitrilase with conserved catalytic triad (Glu-48, Lys-131, Cys-165) which can be used as marker for nitrilase. Conserved regions were identified by performing Multiple Sequence Alignment (MSA) using Multiple EM for Motif Elicitation (.. View More»
DOI: 10.4172/2153-0602.1000119