Mizue Okada
Japan
Research Article
Komatsuna Seed Extracts Protection Against Amyloid β(1-42)-Induced Neuronal Cell Death
Author(s): Yoshinori Okada and Mizue OkadaYoshinori Okada and Mizue Okada
Objective: Alzheimer’s disease (AD) is receiving attention as “Type 3 diabetes” and it is evident that this neurodegenerative disease has multiple shared pathologies with diabetes mellitus. Progressive dementia, increased deposition of amyloid β (Aβ) protein in the brain is the hallmark of AD. Aβ leads to Aβ associated Reactive Oxygen Species (ROS) production and cell death. In this study, we investigated the effects of Komatsuna Seed Extracts (KSE) on Aβ (1-42)-induced neurotoxicity and on the regulation of cell death processing in hippocampus neurons (HN).
Methods: We selected sixteen plants. We investigated the effects of plant seeds’ aqueous extractson (PSAE) on Aβ structure modification using SDS gel electrophoresis. The neuroprotective effects of KSE were evaluated by measuring the cell viability with a CCK-8 assay... View More»
