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Min Wei
Min Wei
Japan
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Review Article
Threshold in Carcinogenicity of Genotoxic Carcinogens
Author(s): Anna Kakehashi, Shoji Fukushima, Min Wei and Hideki WanibuchiAnna Kakehashi, Shoji Fukushima, Min Wei and Hideki Wanibuchi
Nowadays the idea of threshold in the carcinogenicity of chemical carcinogens has attracted interest in the field of carcinogenesis. With genotoxic agents there is considerable experimental evidence in support of the idea. Here, we report on the low dose carcinogenicity in rats observed with heterocyclic amines contained in cooked food, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-amino-3- methylimidazo[4,5-f]quinoline (IQ) and 2-amino- 1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP), and contaminants of natural and manufactured food products, N-nitrosocompounds such as N-nitrosodiethylamine (DEN) and N-nitrosodimethylamine (DMN). The existence of a no-effect level for MeIQx carcinogenicity was confirmed in a medium-term rat liver bioassay. Treatment with increasing doses of MeIQx caused sequence of events to occur in the liver tissue: first, the induction of DNA-MeIQx add.. View More»
DOI: 10.4172/2157-2518.S3-006